Custom Monoclonal Antibody Discovery Services
Cutting-edge science requires reliable, validated antibodies against your specific target. Sometimes, these aren’t available off the shelf. At Fortis Life Sciences®, we offer recombinant monoclonal antibody development services supported by a team with over 50 years of antibody development and manufacturing experience.
A White Glove Experience
We deliver a concierge service from project design through to delivery of your custom antibody. Beginning with detailed discussions to understand your project goals, our technical team works with you to craft an antibody development plan that meets your needs.
Pricing and milestones are established following detailed discussions regarding the scope of work, including:
- Target
- Design goals
- Deliverables
Antigens Designed and Purified In-House
We purify native antigens and produce both recombinant proteins and synthetic peptides in-house. That means we have complete control over their design and QC. And because we make our recombinant protein antigens, we can target proteins and protein isoforms that may otherwise not be commercially available.
Our scientists excel at making custom antibodies to:
- Cell surface, secreted, and intracellular targets
- Anti-idiotype antibodies
- Post-translational modifications (phospho-specific antibodies)
- Small molecules
Recombinant Monoclonal Antibodies
All projects utilize target-specific B cell selection, which yields robust numbers of recombinant rabbit monoclonal antibody candidates for screening. Our robust monoclonal antibody generation platform delivers diverse clone sets, enabling you to discover and validate fit-for-purpose monoclonal antibodies.
Design goals may include:
- Performance in western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation ELISA, or flow cytometry
- Epitope binning to find compatible pairs of antibodies
Milestone-based Project Design
Our milestone design puts you in control of your custom antibody development project. We generate numerous candidates for you to test in your own assays and you tell us which clones work the way you need them to. This strategy reduces the risk of failures and expensive repeats, stacking the deck as heavily as possible in your favor.
Deliverables may include:
- Recombinant rabbit monoclonal antibody that performs in the desired application(s)
- The formulation and scale you need from milligrams to grams
- Shortest possible timeline to meet your deadline
Our Areas of Expertise
Target Types
Cell surface, secreted and intracellular targets
Anti-idiotype antibodies
Post-translational modifications (Phospho-specific antibodies)
Small molecules
Additional Services
Binding pair selection by competition binning
Monoclonal antibody reformatting
Antibody Generation Process
Learn How Our Customers Are Leveraging Bethyl Custom Antibody Services
"We’ve been consistently pleased by Fortis’s initial candidate success rate. We’re now engaged in multiple projects with Fortis, with several anti-PTM clones about to be launched as formal genomic mapping reagents."
Michael-Christopher Keogh, PhD
Chief Scientific Officer
EpiCypher Inc.
"Some companies only splenectomize and proceed with one rabbit, whereas Fortis immunizes multiple rabbits, and these are all screened for antibodies to provide a distribution of the best potential candidates. In this way, we receive multiple options for performing our own screens."
Lori Kobayashi
Project Manager
Valted Seq
"The whole process has been very easy, because Fortis cloned each B cell, enabling it to produce more antibodies and generate high yields."
Bijan Etemad-Gilbertson, PhD
Head of Antibody Technology
NextPoint Therapeutics
